Posted by MTC April 24, 2020
In addition to downregulation on CB1 receptor density, the endogenous cannabinoid anandamide is downregulated in striatal areas after repeated administration of THC in rodents100. Lower levels of anandamide have also been found in the cerebrospinal fluid of people who use cannabis101, although the activity of FAAH is lower in the brain of what is alcoholism people who use cannabis102 (FIG. 4). The full effects of chronic cannabis exposure in the cannabinoid system have not yet been elucidated. Diagnostically, our results underscore the need for clinicians to recognize the diverse symptom presentations of cannabis dependence. The contrast between the mono-factorial structure of cannabis dependence and its heterogeneous clinical presentation suggests three potential approaches to treatment development.
The most effective prevention approaches for alcohol and tobacco are to reduce supply (for example, through pricing, taxation and introducing https://salonsbyjc.com/myths-facts-about-cannabis/ legal restrictions on minimum purchasing age) and to restrict advertising194,195. The same strategies are likely to be effective in jurisdictions that have legalized the retail sale of medicinal and recreational cannabis (BOX 1). In regions where cannabis is illegal, prevention approaches have included media campaigns, and primary (universally applied) and secondary (selectively applied to higher risk populations, including cannabis users) individual-based, school-based, family-based and community-based programmes. Mass media approaches to prevention are typically delivered as short ‘advertisement’ campaigns that present positive role models who reject substance use. There is conflicting evidence on whether these campaigns reliably reduce drug use16,17. A range of biological factors, psychological factors and social factors shape an individual’s vulnerability.
Relapse has been modelled in animal studies using the self-administration paradigm and drug-seeking after abstinence88. In humans, relapse is often observed after exposure to drugs, drug-related stimuli or stressful events. The same stimuli can reinstate drug-seeking in laboratory animals so these studies cannabis use disorder can help to understand why people who use cannabis relapse. Relapse is a complex phenomenon that likely involves multiple brain areas such as the nucleus accumbens, amygdala, prefrontal cortex and insula (FIG. 3)90–92.
It’s important to recognize early signs of the transition from recreational use to dependency. Awareness of these signs can be instrumental in identifying and addressing problematic marijuana use before it escalates into a full-blown disorder. Recognizing these signs is the first step towards seeking help and potentially preventing the deepening of dependency. Clinical Advisor, a trusted source of medical news and feature content for healthcare providers, offers clinicians insight into the latest research to inform clinical practice and improve patient outcomes. Approximately 4.8 million people 12 years or older (or 1.8%) had cannabis use disorder in the past year, according to 2019 data from the National Survey on Drug Use and Health.1 This rate has remained relatively stable since 2002 (Figure). Is a medical writer with a knack for turning complex billing and healthcare topics into clear, actionable insights.
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